Extremely negatively.

The reason is a subtle one, and best captured by the William James quote, "The progress from brute to man is characterized by nothing so much as by the decrease in frequency of proper occasions for fear"

Why, you might ask, might "frequent, proper occasions for fear" be a healthy environment?

Before: life was "long periods of idleness, punctuated by moments of sheer panic" as it is sometimes called.

After: life was constant stress.

Hunting-gathering and pastoral nomadism both are somewhat predatory modes of life. All you have to do is follow your food around. Agriculture on the other hand requires constant and continuous effort, in proportion to value realized. It has you thinking at unnaturally long temporal scales and worrying about events months ahead of time.

Our stress response system is designed for the idleness/panic pattern (like gazelles... mostly you're peacefully chomping on grass, but when the lion shows up, you get your moments of sheer panic).



When this system is basically in a continuously activated mode due to the chronic low-grade stress induced by agricultural lifestyles, our bodies are flooded with stress response biochemistry that leads to a lot of our physical and mental problems. This is because our minds and bodies don't really have a setting for "low grade stress" at all. It's designed more like an on/off switch. You are either relaxed or in fight/flight mode.

Robert Sapolsky's book, Why Zebras Don't Get Ulcers, is a particularly good look at this effect.